Senescent cells build up with age and release inflammatory signals. Here is what early senolytic studies and a 12-week exercise study found, and what they did not show.
Category: Longevity & Healthy Aging
VO2 Max and Longevity: Why Cardiorespiratory Fitness Matters
VO2 max measures how well your body uses oxygen, and large studies link higher fitness with lower risk of death from any cause. Here is what the research shows and how fitness can be built.
Epigenetic Clocks and the Pace of Aging: What Recent Trials Show
Epigenetic clocks read DNA methylation to estimate how fast you are aging. Here is what the CALERIE and DO-HEALTH trials found, and how to think about these tests.
Grip Strength as a Longevity Biomarker: What Large Cohorts Show
Handgrip strength tracks with mortality risk in large open-access cohorts from Europe and the U.S. Here is how to use it as a functional longevity biomarker without overreading a single number.
Extra Virgin Olive Oil and Brain Aging: What Recent Trials Show
By Dr. Ryan Kneessi, ND · Move Forward Natural Health, Odenton, MD · Last reviewed: October 15, 2026 Quick answer: Extra virgin olive oil is more than a cooking fat. Small human trials suggest that daily intake of high-phenolic extra virgin olive oil is linked with better clinical dementia ratings, stronger blood–brain barrier function on […]
Muscle, Strength & Healthy Aging
Creatine, whey protein, urolithin A, omega-3s and vitamin D that support building and keeping muscle with age. Educational information from Dr. Ryan Kneessi, ND, with a link to the products he uses on Fullscript.
Longevity Foundation
Core nutrients that support mitochondrial energy, NAD+ levels and cellular renewal for healthy aging. Educational information from Dr. Ryan Kneessi, ND, with a link to the products he uses on Fullscript.
Who Should Consider Vitamin K2 (MK-7)? Bones, Arteries, Safety
Why vitamin K2 (MK-7) pairs with vitamin D, who may benefit, food sources, and important blood-thinner safety notes from a Maryland ND.
Hydration for Longevity: Water, Electrolytes and Water Quality
Why hydration matters for energy, digestion and brain function, how to add electrolytes naturally, and how to choose cleaner drinking water.
Functional Lab Testing for Longevity: What It Can Show
What functional lab testing can add for complex cases: organic acids, hormone panels, gut testing, inflammation and advanced cardiometabolic markers.