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Category: Gut Health
Introduction to Leaky Gut
Leaky gut is a term used as a simple explanation for increased intestinal permeability. Imagine your intestines as a long hose. If the hose is not damaged, then water will move freely through one end and out the other side. Now, imagine that same hose with tiny punctures. The water now leaks out before reaching […]
Structure and Function of the Gut Barrier
The gut barrier is the first line of defense against foreign substances and pathogens that enter the body through the gastrointestinal tract. It is a complex system composed of physical, chemical, and biological components that work together to protect the body while allowing the absorption of nutrients and water. Structure of Gut Barrier The gut […]
Intestinal Epithelial Cells & Tight Junctions
Intestinal Epithelial Cells The intestinal epithelial cells (IECs) play a critical role in the maintenance of gut barrier function. These cells line the intestinal wall and form a physical and functional barrier between the gut lumen and the bloodstream, regulating the passage of nutrients, water, and other substances. The integrity of the IECs is vital […]
Gut-Associated Lymphoid Tissue
The gut is home to the largest collection of immune cells in the body. The gut-associated lymphoid tissue (GALT) is the collection of immune cells and tissues that are located in the gastrointestinal tract. It is estimated that approximately 70% of the body’s immune cells are located in the gut. Key components of GALT Peyer’s […]
The Gut Microbiome
The human gut is home to a complex community of microorganisms collectively known as the gut microbiota. These microorganisms play a vital role in maintaining gut health and overall well-being. The gut microbiota is primarily composed of bacteria, but it also includes other microorganisms such as archaea, fungi, and viruses. However, bacteria are the most […]
The Gut-Brain Axis
The gut-brain axis consists of the central nervous system (CNS), autonomic nervous system (ANS), hypothalamic-adrenal-pituitary (HPA) axis, and the gastrointestinal tract’s innervation, also known as the enteric nervous system. Neural and hormonal communication pathways allow the brain to influence intestinal activities, which are also under the direct influence of the gut microbiota. The gut-brain axis […]
The Gut Microbiome
The human gut is home to a complex community of microorganisms collectively known as the gut microbiota. These microorganisms play a vital role in maintaining gut health and overall well-being. The gut microbiota is primarily composed of bacteria, but it also includes other microorganisms such as archaea, fungi, and viruses. However, bacteria are the most […]
The Gut-Brain Axis
Introduction to the Gut-Brain Axis The gut-brain axis is a complex and intricate communication network between the gut and the brain. This connection involves a bidirectional signaling pathway that is constantly communicating between the two systems. The gut-brain axis has gained significant attention in recent years due to its potential role in the development and […]
Microbial Diversity and Dysbiosis
The diversity and balance of the gut microbiome is essential for optimal gut function and overall health. Dysbiosis, which is an imbalance of the gut microbiome, has been linked to various health problems, including Leaky Gut. Microbial Diversity Microbial diversity, as it relates to gut health, refers to the variety and abundance of different microorganisms […]