Longevity Foundation is the simplest place to start if you want to support healthy aging at the level of your cells. It focuses on a few core processes that tend to slow down with age, especially energy production, cellular cleanup and a balanced inflammatory response.
Creating a Fullscript account is free, and you can look through every product before you decide anything.
The mechanisms this protocol supports
Every cell depends on mitochondria to turn food into usable energy, and mitochondrial efficiency tends to decline as we get older. NAD+ is a molecule that mitochondria need for energy production and that cells also use for DNA repair, and NAD+ levels drop over the years.
Cells also need a way to clear out damaged parts, a process called autophagy, and a specific version called mitophagy recycles worn-out mitochondria. When cleanup slows down and low-grade inflammation builds, researchers often describe the result as inflammaging.
Research has linked declines in mitochondrial function, lower NAD+ levels and chronic low-grade inflammation with age-related changes in energy, muscle and cognition. This protocol is designed to support those underlying mechanisms rather than any single condition.
What is in the protocol
The exact products and directions are listed in the Fullscript plan, and here is what each one is commonly used to support.
- Mitochondrial NRG from Designs for Health is a blend of nutrients that support mitochondrial energy production.
- ProOmega-D from Nordic Naturals provides the omega-3 fats EPA and DHA along with vitamin D, which together support cell membranes, immune signaling and a balanced inflammatory response.
- Mitopure from Timeline provides urolithin A, which is being studied for its role in mitophagy, the process cells use to recycle worn-out mitochondria.
- NiaCel from Thorne provides nicotinamide riboside, which the body uses to make NAD+, a molecule that cells rely on for energy production and DNA repair.
Related protocols you may find helpful include my tiered longevity protocols and Cellular Energy & Recovery.
How to use it thoughtfully
- Please talk with your provider before starting, especially if you take medications, are pregnant or nursing, or have a health condition.
- This page does not list amounts, so follow the label or the specific guidance your provider gives you.
- When you can, add one product at a time so it is easier to notice how you feel.
- Sleep, nourishing food, daily movement and stress care are the foundation, and supplements are meant to build on them.
Frequently asked questions
How is Longevity Foundation different from the tiered longevity protocols?
Longevity Foundation focuses on mitochondrial energy, NAD+ and cellular renewal, while the Beginner, Intermediate and Advanced tiers focus more on antioxidant defense, DNA repair and telomere support.
Can I take Longevity Foundation with other protocols?
Many people combine it with other protocols, but some products overlap, so it is best to review the full list with your provider before you stack anything.
Do I need an appointment to order these products?
No, you can create a free Fullscript account and order directly, although I always recommend checking with your own provider first, and a free 15-minute consult is available if you would like to talk it through.
Ready to see the full protocol?
Every product I use for this protocol is waiting for you in my Fullscript dispensary.
Not sure this is the right fit for you? Book a free 15-minute consult and we can talk it through together.
Educational purposes only. This page shares general information and is not medical advice. These statements have not been evaluated by the Food and Drug Administration, and these products are not intended to replace care from your own healthcare provider. Please talk with your provider before starting any supplement, especially if you take medications, are pregnant or nursing, or have a health condition.
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