Quick answer
Pendulum lists Akkermansia at 1 capsule daily with food, with 8 ounces of water or another beverage, or as recommended by your healthcare practitioner. Each capsule contains 100 million AFU of Akkermansia muciniphila WB-STR-0001 plus 276 mg of chicory inulin. The label says to refrigerate it for best quality.
Key takeaways
This guide covers a probiotic built around Akkermansia muciniphila, a gut microbe studied for its role in the gut lining and metabolism.
The product is taken with food and needs refrigeration, and the article notes that its prebiotic fiber can cause gas for some people at first.
Early human research is small, so the article encourages checking with a clinician if you are pregnant, nursing or taking medications.
If you have questions about whether Akkermansia fits your plan, a short call is a simple place to start.
Akkermansia muciniphila is a gut bacterium that lives in the mucus layer of the intestine. Pendulum was one of the first companies to sell it as a supplement. This page covers the label directions, storage, and cautions. It is educational information. For general probiotic timing, see Best time to take probiotics.
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What is in it
According to the label on Fullscript, each capsule contains 100 million AFU (active fluorescent units) of Akkermansia muciniphila strain WB-STR-0001 and 276 mg of chicory inulin. Pendulum also makes higher-count PRO versions, which have their own labels.
Label dosing and storage
Adults take 1 capsule daily with food, or as recommended by your healthcare practitioner, with 8 ounces of water or your favorite beverage. Refrigerate it for optimal quality.
Start-low and timing
Some people take it every other day for the first week if the inulin causes gas. This is a general description of how labels are often paced, so please follow the plan your own clinician gives you.
Many people take it with breakfast. If you take antibiotics, many practitioners space probiotics a couple of hours from the dose.
What the research says
In a small proof-of-concept study, adults with overweight or obesity took Akkermansia muciniphila (live or pasteurized) or placebo for 3 months, and researchers measured metabolic markers (Depommier 2019). That study used a different strain preparation and dose from this product. Research on Akkermansia in people is still early.
Cautions and who should check with a provider
Ask first if you are pregnant or nursing, or take medications, as the label states. People who are seriously ill, have a weakened immune system, or have a central line should ask their medical team before taking any live probiotic, and people sensitive to inulin may notice gas or bloating.
Questions to bring to your clinician
These questions can help you get the most out of your next visit.
Would an Akkermansia probiotic make sense for my gut and metabolic goals?
Could an Akkermansia probiotic interact with any of my current medications or other supplements?
Would any labs or health history details help us decide whether an Akkermansia probiotic makes sense for me?
How would we tell whether an Akkermansia probiotic is a good fit for me, and when should we check in again?
Practitioner-grade options in my Fullscript catalog: if you and your clinician decide a supplement makes sense, my supplement guide by health goal links to the practitioner-grade products I trust.
Frequently asked questions
How do I take Pendulum Akkermansia?
The label says 1 capsule daily with food and 8 ounces of water or another beverage.
Does Pendulum Akkermansia need to be refrigerated?
The label says to refrigerate it for optimal quality.
What strain is in Pendulum Akkermansia?
Akkermansia muciniphila WB-STR-0001, at 100 million AFU per capsule.
Can I take Akkermansia with other probiotics?
Many people do. Ask your provider how it fits with your other supplements.
Can I take Pendulum Akkermansia with metformin?
Check with your own doctor or pharmacist before combining a probiotic with diabetes medication.
Can I take Akkermansia with fiber?
Yes. Fiber and prebiotics are often used alongside it.
Can I take Akkermansia with coffee?
Take it with water or a cool drink. Very hot drinks are usually avoided with live probiotics.
How long should I take Akkermansia?
Your clinician can tell you how long it fits your plan.
Related reading
- Best time to take probiotics
- How to take Ther-Biotic Complete
- How to take Metagenics UltraFlora
- How to take Sunfiber
Sources
- Fullscript catalog. Pendulum Akkermansia: Supplement Facts and suggested use.
- Depommier C, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019. PubMed 31263284
- Hill C, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014. PubMed 24912386
Talk with your own doctor or healthcare provider about the right dose for you before starting any supplement, especially if you’re pregnant, nursing, or take medications.
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If you have questions about whether Akkermansia fits your plan, a short call is a simple place to start.
This page shares general educational information and is not medical advice. These statements have not been evaluated by the Food and Drug Administration. Talk with your healthcare provider before starting any supplement, especially if you take medications, are pregnant or nursing, or have a health condition. Product labels can change, so always follow the label on the bottle you have.
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