Quick answer: Chronic inflammation is a prolonged, low-grade immune response that often goes unnoticed. Inflammatory messengers such as TNF-alpha and interleukins can loosen the tight junctions in the gut lining and disturb the microbiome. A weaker barrier then lets more bacterial products into the body, which can keep the inflammation going.
Understanding chronic inflammation
Inflammation is the body’s natural response to injury or infection. When it persists beyond its purpose, it becomes chronic and can damage healthy tissue.
The leaky gut connection
Increased intestinal permeability happens when tight junctions are compromised. See introduction to leaky gut.
Pro-inflammatory cytokines
Chronic inflammation increases cytokines such as interleukin-1 beta, interleukin-6 and TNF-alpha, which can loosen tight junctions.
Damage to the intestinal barrier
Inflammation can damage the single layer of cells lining the gut and the mucus that protects it.
Altered gut microbiome
Inflammation shifts the balance of gut bacteria, which can further weaken the barrier. See dysbiosis.
Inflammation and healthy aging
Chronic, low-grade inflammation is one of the central drivers of aging, sometimes called inflammaging. The gut is a major source of it. Read more in inflammaging or check your level with hs-CRP.
Ways to calm inflammation
- Eat colorful plants, omega-3-rich fish and olive oil
- Limit ultra-processed foods, sugar and alcohol
- Move daily and sleep seven to nine hours
- Manage stress
When to see a naturopathic doctor
- Ongoing bloating, gas, diarrhea or constipation
- Food reactions that seem to be multiplying
- Fatigue, skin flares or joint aches alongside gut symptoms
- You want a personalized gut plan instead of guessing
See a medical provider promptly for blood in your stool, black stools, unexplained weight loss, persistent vomiting, severe abdominal pain, fever, or trouble swallowing.
Want help finding the root of your gut symptoms?
A free 15-minute consultation with Dr. Kneessi. No cost, no obligation. In-office in Odenton, MD or by telehealth.
Frequently asked questions
Can inflammation cause leaky gut?
Chronic inflammation can weaken tight junctions and contribute to increased permeability.
Can leaky gut cause inflammation?
A weaker barrier may let bacterial products like LPS into the blood, fueling inflammation.
How do I know if I have chronic inflammation?
Symptoms are often vague. Tests like hs-CRP can help.
What diet reduces inflammation?
A whole-food, plant-rich diet with healthy fats.
Sources
This article is for educational purposes only and is not medical advice. It does not replace an individual evaluation. Talk with your healthcare provider before starting supplements or changing medications, especially if you are pregnant, nursing, or managing a health condition.
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