Detoxification is defined as the process of removing toxic substances from the body. Dr. Kneessi is a big believer in completing a detox a couple of times every year. Why? Because there are over 80,000 chemicals registered for use in the united states. 80,000!!!!! It’s common to be exposed to over 100 chemicals before you even leave your house in the morning. Xenobiotics are substances that are foreign to the body, aka not produced by the body and therefore not expected to be in the body. Our cells dedicate a large amount of ATP, our chemical energy, towards the process of removing these foreign substances. Removal of toxic build up from our bodies will greatly enhance our organs ability to better absorb nutrients, perform basic biological functions, and stimulate the healing process.
Goals of a Detox
Reduce Toxic Load
Fairly simple math: Decrease toxins in and Increase toxins out
Support Organs of Detoxification
Stimulate specific pathways in the body to support elimination
Repair and Heal Gut
About 3/4th of our immune system cells are located in the gut
Combat Oxidative Stress
Anti-oxidants fight oxidative stress in the body
Increase Energy Levels
Upon completion most people find their energy is sky high
Catch Potential Food Sensitivies
Better understand how food influences mental and physical being
Body burden is defined as the total amount of a chemical present in the body. It’s crazy that we have a term designated towards the amount of chemicals in our bodies. Most people have no idea how toxic our world really is. Toxic load takes into account different factors for each individual such as current state of health, duration of exposures, and our genetics. Healthier individuals are able to tolerate a higher toxic load. Hence why it’s a good idea to support our detoxification processes in the body.
Organ Systems Involved
Our main organ of detoxification is the the liver. Other organs of detoxification include the intestines, kidneys, lungs, and our skin.
Promotes elimination from pathways
- GI tract/Liver/Gall bladder
- Psychological: mental and emotional
Largest gland in human body. Numerous digestive, metabolic, and detoxification roles. Liver cells detoxify pharmaceuticals, xenobiotics, and alcohol. Liver cells also degrade hormones and process many nutrients.
It’s one of the first organs that receives blood from the intestines via the portal vein. Remove amino acids, fatty acids, and glucose from the blood and are stored for later use. Livers phagocytic cells eliminate bacteria that have escaped the intestinal tract and into the blood stream. We will take a deep dive into the detoxification pathways later on.
First area in body where xenobiotics are exposed. Intestines provide a physical barrier to these compounds. Assuming there is no increased intestinal permeability aka leaky gut which allows xenobiotics to skip intestinal detoxification and enter the circulation too early. Having a healthy gut allows the chyme to move through the intestines and for these compounds to be presented to the immune system. The blood is delivered to the liver via the portal vein.
The kidneys main functions are to remove waste from blood, balance body fluids, and form urine. It’s through the production of urine that the nephrons act as filters that clean our blood.
The glomerular capsule contains cells called podocytes which wrap around the capillaries. The blood is filtered here which retains larger molecules as smaller molecules such as water, salt, amino acids, and glucose continue along the process of urine formation (filtrate).
The Integumentary System aka the skin also plays a role in detoxification. First is acts as protection for our internal environment. It houses pain receptors to alert the nervous system of any injuries. Acidic secretions occur which have an anti-bacterial action. The integumentary system can stimulate or inhibit sweat glands which ultimately allows blood from capillary beds to radiate heat through the skin. Sweating is an important component of any detoxification program.
As you can see, this is a very complex detoxification system. Unfortunately, my hand drawing doesn’t do it justice. The simple version of this complex process allows for the liver to detoxify toxic materials via 2 major pathways, Phase 1 and Phase 2. What goes through these phases: drugs, pollutants, xenobiotics, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.
The liver has a high concentration of an enzyme called cytochrome P450. CP450 essentially is responsible for metabolism of xenobiotics, steroids, bile acids, fatty acids, and carcinogens. This enzyme is considered to be part of Phase 1 liver detoxification. Phase 2 detoxification focuses on conjugation pathways.
As you can see, this is a very complex detoxification system. Unfortunately, my hand drawing doesn’t do it justice. The simple version of this complex process allows for the liver to detoxify toxic materials via 2 major pathways, Phase 1 and Phase 2. The liver has a high concentration of an enzyme called cytochrome P450. CP450 essentially is responsible for metabolism of xenobiotics, steroids, bile acids, fatty acids, and carcinogens. This enzyme is considered to be part of Phase 1 liver detoxification. Phase two detoxification involves different mechanisms resulting in conjugation. Conjugation just means the joining of two molecules.
Phase 1 & Phase 2
Cytochrome P450 (phase 1) converts fat-loving (lipophilic) toxins into more water soluble (hydrophilic) intermediates. A series of conjugation enzymes (phase 2) attach certain molecules to the intermediates which results in excretion from the body.
Phase 1 (cytochrome P450 enzymes)
Oxidation, reduction, or hydrolysis reactions occur based on the structure of the xenobiotic. The main objective of this phase is to change the structure of the toxin so we can prepare it for phase 2 and elimination. The main reactions involve the following groups.
- -OH (Hydroxyl group)
- -COOH (carboxyl group)
- -NH2 (Amino group)
Takes a nonpolar lipid-soluble toxin and via the above mention reactions turns the toxin into a more polar and less lipid-soluble state (aka intermediary metabolites). This step enables the pathway to continue down the conjugation pathway (phase 2).
Phase 2 (Conjugation)
The intermediates produced from phase 1 detoxification combine with glucuronic acid, sulfuric acid, glutathione, or other amino acids. This step reduces toxicity of intermediates by converting it into a polar and water soluble product. These are now excreted via stools are urine. If phase 2 is inhibited these intermediates damage proteins, lipids, and DNA.
Other conjugation pathways
- Amino Acid Conjugation: usually glycine, taurine, glutamine
- Methylation: CH3
- Acetylation: CH3-CO
- Glutathione conjugation
After Phase 1
Cytochrome P450 enzymatic reactions result in production of reactive oxygen species (ROS). Free radicals that contain oxygen are called reactive oxygen species
Free radical = an atom or molecule that has one or more unpaired electrons. This imbalance leads to high reactivity which can result in damage to tissues. Anti-oxidants in the diet can help combat oxidative stress.
Try a complete detox
Each kit supplies 1 bottle of Beta-TCP (90T), 1 bottle of Bromelain Plus CLA, 1 container of NutriClear FREE, 1 container of Whey Protein Isolate, and 1 container of the Bio-Detox Packs (30 packs/container). It also includes a blender bottle and a folder with complete instructions. Purchase in our store.
7 Day Detox
Only eat foods from the following list for 7 days. Not to be completed without first consulting with your doctor.
2 meals are usually recommended in addition to a meal replacement shake that supports detoxification.
Tip: check out our shake called nutritional meal supplement found in our store
Chicken Turkey Lamb Buffalo Venison Beef Duck Goose Bison Eggs Boar Rabbit Goat Elk Ostrich TIPS: Grass Fed, Organic, Hormone free options are by far the best. Jerky can be a quick healthy snack option.
Fish / Seafood
Salmon Mahi Mahi Cod Sole Shrimp Lobster Crab Clams Oysters Halibut Mackerel Sardines Trout Walleye Rock Fish Bass Crawfish Scallops TIPS: Wild caught is best option. Try and avoid farm raised.
Asparagus Avocado Broccoli Brussels sprouts Cabbage Carrots Cauliflower Celery Peppers onion all green leafy vegetables Spinach Arugula Spinach Squash Zucchini Eggplant Garlic Shallots Sweet potato Beets Tomato Cucumber Radish Pickles Artichoke Okra Ginger Pumpkin Leeks Parsnips TIPS: If buying all organic is too difficult, remember this general rule of thumb. If the vegetable or fruit has thin skin, you should purchase organic. Thicker skin not as important. For example you should purchase strawberries and apples organic. Avocado not as important. This is due to pesticide exposure.
Apple Strawberry Banana Pineapple Lemon Lime Raspberries Cantaloupe Orange Papaya Kiwi Peaches Plums Mango blueberries Blackberries Grapes Papaya tangerine Dates Figs Apricot Cranberries Raisins Grape fruit Nectarines Honeydew Cherries Pears Watermelon Prunes Pomegranate TIPS: If buying all organic is too difficult, remember this general rule of thumb. If the vegetable or fruit has thin skin, you should purchase organic. Thicker skin not as important. For example you should purchase strawberries and apples organic. Avocado not as important. This is due to pesticide exposure.
Nut’s / Seeds
Almonds Flax seeds Chia seeds Walnuts Macadamia nuts Pumpkin seeds Sunflower seeds Sesame seeds Cashews Hazelnuts Pecans Pine nuts
TIPS: Raw is usually the best option. You will want to avoid added sugars and salt. Nut Butters are an excellent healthy snack option.
Oils / Butter
Coconut Oil Extra Virgin Olive Oil Macadamia oil Grape seed oil Avocado oil Ghee Seseme seed oil Fish oil Flax seed oil Sunflower seed oil Walnut oil
TIPS: When cooking with oils, it’s important not to heat above the smoke point. If your dish starts to smoke on the stove, reduce the heat.
Best to avoid grains during a detox.
Dairy & Dairy Substitutes
Coconut Milk Almond milk Rice milk Cashew milk Hemp milk
Peas Green beans Lentils Chick peas Kidney beans Navy beans Alfalfa Garbanzo beans Black beans Lima beans
TIPS: Hummus is a healthy snack option that you need to get on board with!
Water Herbal teas Green tea
Tips: Most people should drink half their body weight (lbs) in ounces of water. For example: weight 200lbs = 100 oz of water daily.
Basil Cinnamon Cumin Paprika Ginger Nutmeg Thyme Oregano Rosemary Chili powder Curry powder Sage Garlic powder Onion powder Cayenne pepper Bay leaf Black pepper Crushed red pepper Parsley Mint Turmeric Clove Salt (Sea salt & Himalayan salt)
TIPS: You’ll want to stay away from added salts and cream based sauces.
Coconut aminos Apple cider vinegar Cooking wines Vinaigrettes Hot Sauce Honey Maple Syrup
TIPS: Vinaigrettes are great options for salads