Why Detox?

Detoxification is defined as the process of removing toxic substances from the body.  Dr. Kneessi is a big believer in completing a detox a couple of times every year.  Why?  Because there are over 80,000 chemicals registered for use in the united states.  80,000!!!!!  It’s common to be exposed to over 100 chemicals before you even leave your house in the morning.  Xenobiotics are substances that are foreign to the body, aka not produced by the body and therefore not expected to be in the body.  Our cells dedicate a large amount of ATP, our chemical energy, towards the process of removing these foreign substances.  Removal of toxic build up from our bodies will greatly enhance our organs ability to better absorb nutrients, perform basic biological functions, and stimulate the healing process.  

 

Goals of a Detox

Reduce Toxic Load

Fairly simple math: Decrease toxins in and Increase toxins out

Support Organs of Detoxification

Stimulate specific pathways in the body to support elimination

Repair and Heal Gut

About 3/4th of our immune system cells are located in the gut

Combat Oxidative Stress

Anti-oxidants fight oxidative stress in the body

Increase Energy Levels

Upon completion most people find their energy is sky high

Catch Potential Food Sensitivies

Better understand how food influences mental and physical being

Body burden is defined as the total amount of a chemical present in the body.  It’s crazy that we have a term designated towards the amount of chemicals in our bodies.  Most people have no idea how toxic our world really is.  Toxic load takes into account different factors for each individual such as current state of health, duration of exposures, and our genetics.  Healthier individuals are able to tolerate a higher toxic load.  Hence why it’s a good idea to support our detoxification processes in the body.   

Organ Systems Involved

Our main organ of detoxification is the the liver.  Other organs of detoxification include the intestines, kidneys, lungs, and our skin.

Promotes elimination from pathways

  • GI tract/Liver/Gall bladder
  • Kidney/Bladder
  • Lungs/respiration
  • Skin/lymphatics
  • Psychological: mental and emotional

Liver

Largest gland in human body.  Numerous digestive, metabolic, and detoxification roles.  Liver cells detoxify pharmaceuticals, xenobiotics, and alcohol.  Liver cells also degrade hormones and process many nutrients.

 

It’s one of the first organs that receives blood from the intestines via the portal vein.  Remove amino acids, fatty acids, and glucose from the blood and are stored for later use.  Livers phagocytic cells eliminate bacteria that have escaped the intestinal tract and into the blood stream.  We will take a deep dive into the detoxification pathways later on.  

Intestines

First area in body where xenobiotics are exposed.  Intestines provide a physical barrier to these compounds.  Assuming there is no increased intestinal permeability aka leaky gut which allows xenobiotics to skip intestinal detoxification and enter the circulation too early.  Having a healthy gut allows the chyme to move through the intestines and for these compounds to be presented to the immune system. The blood is delivered to the liver via the portal vein.

Kidneys

The kidneys main functions are to remove waste from blood, balance body fluids, and form urine.  It’s through the production of urine that the nephrons act as filters that clean our blood.  

The glomerular capsule contains cells called podocytes which wrap around the capillaries.  The blood is filtered here which retains larger molecules as smaller molecules such as water, salt, amino acids, and glucose continue along the process of urine formation (filtrate).

The skin

The Integumentary System aka the skin also plays a role in detoxification.  First is acts as protection for our internal environment.  It houses pain receptors to alert the nervous system of any injuries.  Acidic secretions occur which have an anti-bacterial action.  The integumentary system can stimulate or inhibit sweat glands which ultimately allows blood from capillary beds to radiate heat through the skin. Sweating is an important component of any detoxification program. 

The Science

As you can see, this is a very complex detoxification system.  Unfortunately, my hand drawing doesn’t do it justice.  The simple version of this complex process allows for the liver to detoxify toxic materials via 2 major pathways, Phase 1 and Phase 2.  What goes through these phases: drugs, pollutants, xenobiotics, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

 

The liver has a high concentration of an enzyme called cytochrome P450.  CP450 essentially is responsible for metabolism of xenobiotics, steroids, bile acids, fatty acids, and carcinogens.  This enzyme is considered to be part of Phase 1 liver detoxification.  Phase 2 detoxification focuses on conjugation pathways.

As you can see, this is a very complex detoxification system.  Unfortunately, my hand drawing doesn’t do it justice.  The simple version of this complex process allows for the liver to detoxify toxic materials via 2 major pathways, Phase 1 and Phase 2.  The liver has a high concentration of an enzyme called cytochrome P450.  CP450 essentially is responsible for metabolism of xenobiotics, steroids, bile acids, fatty acids, and carcinogens.  This enzyme is considered to be part of Phase 1 liver detoxification.  Phase two detoxification involves different mechanisms resulting in conjugation.  Conjugation just means the joining of two molecules.

 

Phase 1 & Phase 2

Cytochrome P450 (phase 1) converts fat-loving (lipophilic) toxins into more water soluble (hydrophilic) intermediates. A series of conjugation enzymes (phase 2) attach certain molecules to the intermediates which results in excretion from the body.

Phase 1 (cytochrome P450 enzymes)

Oxidation, reduction, or hydrolysis reactions occur based on the structure of the xenobiotic.  The main objective of this phase is to change the structure of the toxin so we can prepare it for phase 2 and elimination.  The main reactions involve the following groups. 

  • -OH (Hydroxyl group)
  • -COOH (carboxyl group)
  • -NH2 (Amino group)

Takes a nonpolar lipid-soluble toxin and via the above mention reactions turns the toxin into a more polar and less lipid-soluble state (aka intermediary metabolites).  This step enables the pathway to continue down the conjugation pathway (phase 2).

Phase 2 (Conjugation)

The intermediates produced from phase 1 detoxification combine with glucuronic acid, sulfuric acid, glutathione, or other amino acids.  This step reduces toxicity of intermediates by converting it into a polar and water soluble product.  These are now excreted via stools are urine.  If phase 2 is inhibited these intermediates damage proteins, lipids, and DNA.

Other conjugation pathways

  • Amino Acid Conjugation:  usually glycine, taurine, glutamine
  • Methylation: CH3
  • Acetylation: CH3-CO
  • Glutathione conjugation

After Phase 1

Cytochrome P450 enzymatic reactions result in production of reactive oxygen species (ROS).  Free radicals that contain oxygen are called reactive oxygen species

Free radical = an atom or molecule that has one or more unpaired electrons. This imbalance leads to high reactivity which can result in damage to tissues.  Anti-oxidants in the diet can help combat oxidative stress. 

Try a complete detox

Each kit supplies 1 bottle of Beta-TCP (90T), 1 bottle of Bromelain Plus CLA, 1 container of NutriClear FREE, 1 container of Whey Protein Isolate, and 1 container of the Bio-Detox Packs (30 packs/container). It also includes a blender bottle and a folder with complete instructions.  Purchase in our store.

7 Day Detox

Only eat foods from the following list for 7 days. Not to be completed without first consulting with your doctor.

2 meals are usually recommended in addition to a meal replacement shake that supports detoxification.

Tip: check out our shake called nutritional meal supplement found in our store

Animal Protein

Chicken        Turkey        Lamb        Buffalo        Venison        Beef        Duck        Goose        Bison        Eggs        Boar        Rabbit        Goat        Elk        Ostrich        TIPS: Grass Fed, Organic, Hormone free options are by far the best.  Jerky can be a quick healthy snack option.

Fish / Seafood

Salmon        Mahi Mahi        Cod        Sole        Shrimp        Lobster        Crab        Clams        Oysters        Halibut        Mackerel        Sardines        Trout        Walleye        Rock Fish        Bass        Crawfish        Scallops                                                                                                                                                                      TIPS: Wild caught is best option.  Try and avoid farm raised.

Vegetables

Asparagus        Avocado        Broccoli        Brussels sprouts        Cabbage        Carrots        Cauliflower        Celery        Peppers        onion        all green leafy vegetables        Spinach        Arugula        Spinach        Squash        Zucchini        Eggplant        Garlic        Shallots        Sweet potato        Beets        Tomato        Cucumber        Radish        Pickles        Artichoke        Okra        Ginger        Pumpkin        Leeks        Parsnips                                                                                  TIPS: If buying all organic is too difficult, remember this general rule of thumb.  If the vegetable or fruit has thin skin, you should purchase organic.  Thicker skin not as important.  For example you should purchase strawberries and apples organic.  Avocado not as important.  This is due to pesticide exposure.

Fruits

Apple        Strawberry        Banana        Pineapple        Lemon        Lime        Raspberries        Cantaloupe        Orange        Papaya        Kiwi        Peaches        Plums        Mango        blueberries         Blackberries        Grapes        Papaya        tangerine        Dates         Figs        Apricot        Cranberries        Raisins        Grape fruit        Nectarines        Honeydew        Cherries        Pears        Watermelon        Prunes        Pomegranate                                                                          TIPS: If buying all organic is too difficult, remember this general rule of thumb.  If the vegetable or fruit has thin skin, you should purchase organic.  Thicker skin not as important.  For example you should purchase strawberries and apples organic.  Avocado not as important.  This is due to pesticide exposure.

Nut’s / Seeds

Almonds        Flax seeds        Chia seeds        Walnuts        Macadamia nuts        Pumpkin seeds        Sunflower seeds        Sesame seeds        Cashews        Hazelnuts        Pecans        Pine nuts

TIPS: Raw is usually the best option.  You will want to avoid added sugars and salt.  Nut Butters are an excellent healthy snack option.

Oils / Butter

Coconut Oil        Extra Virgin Olive Oil        Macadamia oil        Grape seed oil        Avocado oil        Ghee        Seseme seed oil        Fish oil        Flax seed oil        Sunflower seed oil        Walnut oil

TIPS: When cooking with oils, it’s important not to heat above the smoke point.  If your dish starts to smoke on the stove, reduce the heat.

Grains

Best to avoid grains during a detox.

Dairy & Dairy Substitutes

Coconut Milk        Almond milk        Rice milk        Cashew milk        Hemp milk

Legumes

Peas        Green beans        Lentils        Chick peas        Kidney beans        Navy beans        Alfalfa        Garbanzo beans        Black beans        Lima beans

TIPS: Hummus is a healthy snack option that you need to get on board with!

Beverages

Water           Herbal teas        Green tea

Tips: Most people should drink half their body weight (lbs) in ounces of water.  For example:  weight 200lbs = 100 oz of water daily.        

Spices

Basil        Cinnamon        Cumin        Paprika        Ginger        Nutmeg        Thyme        Oregano        Rosemary        Chili powder        Curry powder        Sage        Garlic powder        Onion powder        Cayenne pepper        Bay leaf        Black pepper        Crushed red pepper        Parsley        Mint        Turmeric        Clove        Salt (Sea salt & Himalayan salt)

TIPS: You’ll want to stay away from added salts and cream based sauces.

Other

Coconut aminos        Apple cider vinegar            Cooking wines         Vinaigrettes        Hot Sauce        Honey        Maple Syrup

TIPS: Vinaigrettes are great options for salads